Browse result page of PRRDB 2.0

PRRID	Name of Ligand	Source of ligand	Sequence of Ligand	Length of Ligand	Type of Ligand	Occurence	Role of Ligand	Name of Receptor	Type of Reeptor	Source of the Receptor	Localization	Domain	Sequence of Receptor	Swiss prot ID	Length of receptor	Function of Receptor	Assay used	PMID	Year of publication	Pubchem assay
PRRID_0581	IMO-10 Click for more detail	NA	5'-TCG2TCG2TTdUY-M-YdUTTG2CTG2CT-5'	NA	Nucleic Acid	Synthetic	Binding leads to the secretion of cytokines and chemokines such as IL-6, IP-10, IL-12 and MCP-10	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Mice	HEK293 cells, Bcells, PDCs, mDCs, PBMC	Leucine-rich Repeat (LRR) Domain	Q9NR96.fasta	Q9NR96	1032	This has immunostimulatory effect	Cytokines assay	20381019	2010	Pubchem Assay
PRRID_0581	IMO-10 Click for more detail	NA	5'-TCG2TCG2TTdUY-M-YdUTTG2CTG2CT-5'	NA	Nucleic Acid	Synthetic	Binding leads to the secretion of cytokines and chemokines such as IL-6, IP-10, IL-12 and MCP-10	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Mice	HEK293 cells, Bcells, PDCs, mDCs, PBMC	Leucine-rich Repeat (LRR) Domain	Q9NR96.fasta	Q9NR96	1032	This has immunostimulatory effect	Cytokines assay	20381019	2010	Pubchem Assay
PRRID_0582	IMO-11 Click for more detail	NA	5'-TCG1TACG1TACG1-X-G1CATG1CATG1CT-5'	NA	Nucleic Acid	Synthetic	Binding leads to the secretion of cytokines and chemokines such as IL-6, IP-10, IL-12 and MCP-11	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Mice	HEK293 cells, Bcells, PDCs, mDCs, PBMC	Leucine-rich Repeat (LRR) Domain	Q9NR96.fasta	Q9NR96	1032	This has immunostimulatory effect	Cytokines assay	20381019	2010	Pubchem Assay
PRRID_0582	IMO-11 Click for more detail	NA	5'-TCG1TACG1TACG1-X-G1CATG1CATG1CT-5'	NA	Nucleic Acid	Synthetic	Binding leads to the secretion of cytokines and chemokines such as IL-6, IP-10, IL-12 and MCP-11	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Mice	HEK293 cells, Bcells, PDCs, mDCs, PBMC	Leucine-rich Repeat (LRR) Domain	Q9NR96.fasta	Q9NR96	1032	This has immunostimulatory effect	Cytokines assay	20381019	2010	Pubchem Assay
PRRID_0583	IMO-12 Click for more detail	NA	5'-TCG1AACG1TTCoG-Z-GoCTTG1CAAG1CT-5'	NA	Nucleic Acid	Synthetic	Binding leads to the secretion of cytokines and chemokines such as IL-6, IP-10, IL-12 and MCP-12	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Mice	HEK293 cells, Bcells, PDCs, mDCs, PBMC	Leucine-rich Repeat (LRR) Domain	Q9NR96.fasta	Q9NR96	1032	This has immunostimulatory effect	Cytokines assay	20381019	2010	Pubchem Assay
PRRID_0583	IMO-12 Click for more detail	NA	5'-TCG1AACG1TTCoG-Z-GoCTTG1CAAG1CT-5'	NA	Nucleic Acid	Synthetic	Binding leads to the secretion of cytokines and chemokines such as IL-6, IP-10, IL-12 and MCP-12	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Mice	HEK293 cells, Bcells, PDCs, mDCs, PBMC	Leucine-rich Repeat (LRR) Domain	Q9NR96.fasta	Q9NR96	1032	This has immunostimulatory effect	Cytokines assay	20381019	2010	Pubchem Assay
PRRID_0584	IMO-13 Click for more detail	NA	5'-TCG1AACG1TTCG1-L-G1CTTG1CAAG1CT-5'	NA	Nucleic Acid	Synthetic	Binding leads to the secretion of cytokines and chemokines such as IL-6, IP-10, IL-12 and MCP-13	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Mice	HEK293 cells, Bcells, PDCs, mDCs, PBMC	Leucine-rich Repeat (LRR) Domain	Q9NR96.fasta	Q9NR96	1032	This has immunostimulatory effect	Cytokines assay	20381019	2010	Pubchem Assay
PRRID_0584	IMO-13 Click for more detail	NA	5'-TCG1AACG1TTCG1-L-G1CTTG1CAAG1CT-5'	NA	Nucleic Acid	Synthetic	Binding leads to the secretion of cytokines and chemokines such as IL-6, IP-10, IL-12 and MCP-13	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Mice	HEK293 cells, Bcells, PDCs, mDCs, PBMC	Leucine-rich Repeat (LRR) Domain	Q9NR96.fasta	Q9NR96	1032	This has immunostimulatory effect	Cytokines assay	20381019	2010	Pubchem Assay
PRRID_0585	IMO-14 Click for more detail	NA	5'-TCG1AACG1ToTCoG-m-GoCToTG1CAAG1CT-5'	NA	Nucleic Acid	Synthetic	Binding leads to the secretion of cytokines and chemokines such as IL-6, IP-10, IL-12 and MCP-14	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Mice	HEK293 cells, Bcells, PDCs, mDCs, PBMC	Leucine-rich Repeat (LRR) Domain	Q9NR96.fasta	Q9NR96	1032	This has immunostimulatory effect	Cytokines assay	20381019	2010	Pubchem Assay
PRRID_0585	IMO-14 Click for more detail	NA	5'-TCG1AACG1ToTCoG-m-GoCToTG1CAAG1CT-5'	NA	Nucleic Acid	Synthetic	Binding leads to the secretion of cytokines and chemokines such as IL-6, IP-10, IL-12 and MCP-14	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Mice	HEK293 cells, Bcells, PDCs, mDCs, PBMC	Leucine-rich Repeat (LRR) Domain	Q9NR96.fasta	Q9NR96	1032	This has immunostimulatory effect	Cytokines assay	20381019	2010	Pubchem Assay
PRRID_0586	IMO-15 Click for more detail	NA	5'-TCG1AACG1dUdUCoG-M-GoCdUdUG1CAAG1CT-5'	NA	Nucleic Acid	Synthetic	Binding leads to the secretion of cytokines and chemokines such as IL-6, IP-10, IL-12 and MCP-15	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Mice	HEK293 cells, Bcells, PDCs, mDCs, PBMC	Leucine-rich Repeat (LRR) Domain	Q9NR96.fasta	Q9NR96	1032	This has immunostimulatory effect	Cytokines assay	20381019	2010	Pubchem Assay
PRRID_0586	IMO-15 Click for more detail	NA	5'-TCG1AACG1dUdUCoG-M-GoCdUdUG1CAAG1CT-5'	NA	Nucleic Acid	Synthetic	Binding leads to the secretion of cytokines and chemokines such as IL-6, IP-10, IL-12 and MCP-15	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Mice	HEK293 cells, Bcells, PDCs, mDCs, PBMC	Leucine-rich Repeat (LRR) Domain	Q9NR96.fasta	Q9NR96	1032	This has immunostimulatory effect	Cytokines assay	20381019	2010	Pubchem Assay
PRRID_0587	IMO-16 Click for more detail	NA	5'-ACACACCAACT-X-TCAACCACACA-5'	NA	Nucleic Acid	Synthetic	Binding leads to the secretion of cytokines and chemokines such as IL-6, IP-10, IL-12 and MCP-16	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Mice	HEK293 cells, Bcells, PDCs, mDCs, PBMC	Leucine-rich Repeat (LRR) Domain	Q9NR96.fasta	Q9NR96	1032	This has immunostimulatory effect	Cytokines assay	20381019	2010	Pubchem Assay
PRRID_0587	IMO-16 Click for more detail	NA	5'-ACACACCAACT-X-TCAACCACACA-5'	NA	Nucleic Acid	Synthetic	Binding leads to the secretion of cytokines and chemokines such as IL-6, IP-10, IL-12 and MCP-16	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Mice	HEK293 cells, Bcells, PDCs, mDCs, PBMC	Leucine-rich Repeat (LRR) Domain	Q9NR96.fasta	Q9NR96	1032	This has immunostimulatory effect	Cytokines assay	20381019	2010	Pubchem Assay
PRRID_0588	IMO-2 Click for more detail	NA	5'-TCTGTCG2TTCU-X-UCTTG2CTGTCT-5'	NA	Nucleic Acid	Synthetic	Binding leads to the secretion of cytokines and chemokines such as IL-6, IP-10, IL-12 and MCP-2	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Mice	HEK293 cells, Bcells, PDCs, mDCs, PBMC	Leucine-rich Repeat (LRR) Domain	Q9NR96.fasta	Q9NR96	1032	This has immunostimulatory effect	Cytokines assay	20381019	2010	Pubchem Assay
PRRID_0588	IMO-2 Click for more detail	NA	5'-TCTGTCG2TTCU-X-UCTTG2CTGTCT-5'	NA	Nucleic Acid	Synthetic	Binding leads to the secretion of cytokines and chemokines such as IL-6, IP-10, IL-12 and MCP-2	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Mice	HEK293 cells, Bcells, PDCs, mDCs, PBMC	Leucine-rich Repeat (LRR) Domain	Q9NR96.fasta	Q9NR96	1032	This has immunostimulatory effect	Cytokines assay	20381019	2010	Pubchem Assay
PRRID_0589	IMO-3 Click for more detail	NA	5'-TCAGToCG2TTAC-Z-CATTG2CoTGACT-5'	NA	Nucleic Acid	Synthetic	Binding leads to the secretion of cytokines and chemokines such as IL-6, IP-10, IL-12 and MCP-3	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Mice	HEK293 cells, Bcells, PDCs, mDCs, PBMC	Leucine-rich Repeat (LRR) Domain	Q9NR96.fasta	Q9NR96	1032	This has immunostimulatory effect	Cytokines assay	20381019	2010	Pubchem Assay
PRRID_0589	IMO-3 Click for more detail	NA	5'-TCAGToCG2TTAC-Z-CATTG2CoTGACT-5'	NA	Nucleic Acid	Synthetic	Binding leads to the secretion of cytokines and chemokines such as IL-6, IP-10, IL-12 and MCP-3	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Mice	HEK293 cells, Bcells, PDCs, mDCs, PBMC	Leucine-rich Repeat (LRR) Domain	Q9NR96.fasta	Q9NR96	1032	This has immunostimulatory effect	Cytokines assay	20381019	2010	Pubchem Assay
PRRID_0590	IMO-4 Click for more detail	NA	5'-TCTGoToCG2TTAG-M-GATTG2CoToGTCT-5'	NA	Nucleic Acid	Synthetic	Binding leads to the secretion of cytokines and chemokines such as IL-6, IP-10, IL-12 and MCP-4	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Mice	HEK293 cells, Bcells, PDCs, mDCs, PBMC	Leucine-rich Repeat (LRR) Domain	Q9NR96.fasta	Q9NR96	1032	This has immunostimulatory effect	Cytokines assay	20381019	2010	Pubchem Assay
PRRID_0590	IMO-4 Click for more detail	NA	5'-TCTGoToCG2TTAG-M-GATTG2CoToGTCT-5'	NA	Nucleic Acid	Synthetic	Binding leads to the secretion of cytokines and chemokines such as IL-6, IP-10, IL-12 and MCP-4	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Mice	HEK293 cells, Bcells, PDCs, mDCs, PBMC	Leucine-rich Repeat (LRR) Domain	Q9NR96.fasta	Q9NR96	1032	This has immunostimulatory effect	Cytokines assay	20381019	2010	Pubchem Assay
PRRID_0591	IMO-5 Click for more detail	NA	5'-CAGTCoG2TTCAG-Z-GACTTG2oCTGAC-5'	NA	Nucleic Acid	Synthetic	Binding leads to the secretion of cytokines and chemokines such as IL-6, IP-10, IL-12 and MCP-5	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Mice	HEK293 cells, Bcells, PDCs, mDCs, PBMC	Leucine-rich Repeat (LRR) Domain	Q9NR96.fasta	Q9NR96	1032	This has immunostimulatory effect	Cytokines assay	20381019	2010	Pubchem Assay
PRRID_0591	IMO-5 Click for more detail	NA	5'-CAGTCoG2TTCAG-Z-GACTTG2oCTGAC-5'	NA	Nucleic Acid	Synthetic	Binding leads to the secretion of cytokines and chemokines such as IL-6, IP-10, IL-12 and MCP-5	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Mice	HEK293 cells, Bcells, PDCs, mDCs, PBMC	Leucine-rich Repeat (LRR) Domain	Q9NR96.fasta	Q9NR96	1032	This has immunostimulatory effect	Cytokines assay	20381019	2010	Pubchem Assay
PRRID_0592	IMO-6 Click for more detail	NA	5'-TCG1TCG1TTTY-M-YTTTG1CTG1CT-5'	NA	Nucleic Acid	Synthetic	Binding leads to the secretion of cytokines and chemokines such as IL-6, IP-10, IL-12 and MCP-6	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Mice	HEK293 cells, Bcells, PDCs, mDCs, PBMC	Leucine-rich Repeat (LRR) Domain	Q9NR96.fasta	Q9NR96	1032	This has immunostimulatory effect	Cytokines assay	20381019	2010	Pubchem Assay
PRRID_0592	IMO-6 Click for more detail	NA	5'-TCG1TCG1TTTY-M-YTTTG1CTG1CT-5'	NA	Nucleic Acid	Synthetic	Binding leads to the secretion of cytokines and chemokines such as IL-6, IP-10, IL-12 and MCP-6	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Mice	HEK293 cells, Bcells, PDCs, mDCs, PBMC	Leucine-rich Repeat (LRR) Domain	Q9NR96.fasta	Q9NR96	1032	This has immunostimulatory effect	Cytokines assay	20381019	2010	Pubchem Assay
PRRID_0593	IMO-7 Click for more detail	NA	5'-TCG1TCG1TTTY-X-YTTTG1CTG1CT-5'	NA	Nucleic Acid	Synthetic	Binding leads to the secretion of cytokines and chemokines such as IL-6, IP-10, IL-12 and MCP-7	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Mice	HEK293 cells, Bcells, PDCs, mDCs, PBMC	Leucine-rich Repeat (LRR) Domain	Q9NR96.fasta	Q9NR96	1032	This has immunostimulatory effect	Cytokines assay	20381019	2010	Pubchem Assay
PRRID_0593	IMO-7 Click for more detail	NA	5'-TCG1TCG1TTTY-X-YTTTG1CTG1CT-5'	NA	Nucleic Acid	Synthetic	Binding leads to the secretion of cytokines and chemokines such as IL-6, IP-10, IL-12 and MCP-7	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Mice	HEK293 cells, Bcells, PDCs, mDCs, PBMC	Leucine-rich Repeat (LRR) Domain	Q9NR96.fasta	Q9NR96	1032	This has immunostimulatory effect	Cytokines assay	20381019	2010	Pubchem Assay
PRRID_0594	IMO-8 Click for more detail	NA	5'-TCG1TCG1TTTUU-X-UUTTTG1CTG1CT-5'	NA	Nucleic Acid	Synthetic	Binding leads to the secretion of cytokines and chemokines such as IL-6, IP-10, IL-12 and MCP-8	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Mice	HEK293 cells, Bcells, PDCs, mDCs, PBMC	Leucine-rich Repeat (LRR) Domain	Q9NR96.fasta	Q9NR96	1032	This has immunostimulatory effect	Cytokines assay	20381019	2010	Pubchem Assay
PRRID_0594	IMO-8 Click for more detail	NA	5'-TCG1TCG1TTTUU-X-UUTTTG1CTG1CT-5'	NA	Nucleic Acid	Synthetic	Binding leads to the secretion of cytokines and chemokines such as IL-6, IP-10, IL-12 and MCP-8	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Mice	HEK293 cells, Bcells, PDCs, mDCs, PBMC	Leucine-rich Repeat (LRR) Domain	Q9NR96.fasta	Q9NR96	1032	This has immunostimulatory effect	Cytokines assay	20381019	2010	Pubchem Assay
PRRID_0595	IMO-9 Click for more detail	NA	5'-TCG1TCG1TTdUY-Z-YdUTTG1CTG1CT-5'	NA	Nucleic Acid	Synthetic	Binding leads to the secretion of cytokines and chemokines such as IL-6, IP-10, IL-12 and MCP-9	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Mice	HEK293 cells, Bcells, PDCs, mDCs, PBMC	Leucine-rich Repeat (LRR) Domain	Q9NR96.fasta	Q9NR96	1032	This has immunostimulatory effect	Cytokines assay	20381019	2010	Pubchem Assay
PRRID_0595	IMO-9 Click for more detail	NA	5'-TCG1TCG1TTdUY-Z-YdUTTG1CTG1CT-5'	NA	Nucleic Acid	Synthetic	Binding leads to the secretion of cytokines and chemokines such as IL-6, IP-10, IL-12 and MCP-9	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Mice	HEK293 cells, Bcells, PDCs, mDCs, PBMC	Leucine-rich Repeat (LRR) Domain	Q9NR96.fasta	Q9NR96	1032	This has immunostimulatory effect	Cytokines assay	20381019	2010	Pubchem Assay
PRRID_0597	IVT-RNA Click for more detail	NA	NA	NA	Nucleic Acid	Synthetic	Upon recognition, these domains allow for CARD‚ÄìCARD interaction with the mitochondrial adaptor proteins MAVS, which leads to the secretion of type-I interferons	RIG-1	Rig-like receptor (RLR)	NA	NA	NA	NA	NA	NA	IFN triggers the expression of antiviral proteins, promote the destruction of infected cells by natural killer cells, and facilitate the production of neutralizing antibodies and cytotoxic T-cell responses.	NA	20354786	2010	NA
PRRID_0597	IVT-RNA Click for more detail	NA	NA	NA	Nucleic Acid	Synthetic	Upon recognition, these domains allow for CARD‚ÄìCARD interaction with the mitochondrial adaptor proteins MAVS, which leads to the secretion of type-I interferons	RIG-1	Rig-like receptor (RLR)	NA	NA	NA	NA	NA	NA	IFN triggers the expression of antiviral proteins, promote the destruction of infected cells by natural killer cells, and facilitate the production of neutralizing antibodies and cytotoxic T-cell responses.	NA	20354786	2010	NA
PRRID_0661	Loxoribine (7-allyl-7,8-dihydro-8-oxo-guanosine) Click for more detail	Guanosine (others)	C=CCN1C2=C(NC(=NC2=O)N)N(C1=O)C3C(C(C(O3)CO)O)O	NA	Nucleic Acid	Synthetic	It produce pro-inflammatory cytokines including IFNŒ±, TNFŒ± and/or IL-12	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	DCs, monocytes, macrophages, lymphocytes, Langerhans cells, and NK cells	Leucine-rich Repeat (LRR) Domain	Q9NYK1.fasta	Q9NYK1	1049	Itresults into the inflammatory response	NA	20713100	2010	Pubchem Assay
PRRID_0661	Loxoribine (7-allyl-7,8-dihydro-8-oxo-guanosine) Click for more detail	Guanosine (others)	C=CCN1C2=C(NC(=NC2=O)N)N(C1=O)C3C(C(C(O3)CO)O)O	NA	Nucleic Acid	Synthetic	It produce pro-inflammatory cytokines including IFNŒ±, TNFŒ± and/or IL-12	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	DCs, monocytes, macrophages, lymphocytes, Langerhans cells, and NK cells	Leucine-rich Repeat (LRR) Domain	Q9NYK1.fasta	Q9NYK1	1049	Itresults into the inflammatory response	NA	20713100	2010	Pubchem Assay
PRRID_0662	Loxoribine (7-allyl-7,8-dihydro-8-oxo-guanosine) Click for more detail	Guanosine (others)	C=CCN1C2=C(NC(=NC2=O)N)N(C1=O)C3C(C(C(O3)CO)O)O	NA	Nucleic Acid	Synthetic	It produce pro-inflammatory cytokines including IFNŒ±, TNFŒ± and/or IL-12	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	DCs, monocytes, macrophages, lymphocytes, Langerhans cells, and NK cells	Leucine-rich Repeat (LRR) Domain	Q9NR97.fasta	Q9NR97	1041	Itresults into the inflammatory response	NA	20713100	2010	Pubchem Assay
PRRID_0662	Loxoribine (7-allyl-7,8-dihydro-8-oxo-guanosine) Click for more detail	Guanosine (others)	C=CCN1C2=C(NC(=NC2=O)N)N(C1=O)C3C(C(C(O3)CO)O)O	NA	Nucleic Acid	Synthetic	It produce pro-inflammatory cytokines including IFNŒ±, TNFŒ± and/or IL-12	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	DCs, monocytes, macrophages, lymphocytes, Langerhans cells, and NK cells	Leucine-rich Repeat (LRR) Domain	Q9NR97.fasta	Q9NR97	1041	Itresults into the inflammatory response	NA	20713100	2010	Pubchem Assay
PRRID_0663	Loxoribine (7-allyl-7,8-dihydro-8-oxo-guanosine) Click for more detail	NA	C=CCN1C2=C(NC(=NC2=O)N)N(C1=O)C3C(C(C(O3)CO)O)O	NA	Nucleic Acid	Synthetic	It led to the activation of NF-Œ∫B and upregulate the expression of the antiapoptotic protein Bcl-2.	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	Lung cancer cells	NA	Q9NYK1.fasta	Q9NYK1	1049	This resulted into increased tumor cell survival and resistance to apoptosis induced by chemotherapy.	ELISA	20237413	2010	Pubchem Assay
PRRID_0663	Loxoribine (7-allyl-7,8-dihydro-8-oxo-guanosine) Click for more detail	NA	C=CCN1C2=C(NC(=NC2=O)N)N(C1=O)C3C(C(C(O3)CO)O)O	NA	Nucleic Acid	Synthetic	It led to the activation of NF-Œ∫B and upregulate the expression of the antiapoptotic protein Bcl-2.	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	Lung cancer cells	NA	Q9NYK1.fasta	Q9NYK1	1049	This resulted into increased tumor cell survival and resistance to apoptosis induced by chemotherapy.	ELISA	20237413	2010	Pubchem Assay
PRRID_0680	Mitochondrial DNA Click for more detail	rhabdomyosarcoma cells (others)	NA	NA	Nucleic Acid	Natural	It activates the PMN in circukation and promote the Ca2+ flux and phosphorylation of MAP kinases	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human	Neutrophils	NA	Q9NR96.fasta	Q9NR96	1032	It incites non-specific organ attack and suppresses chemotactic responsess to infective stimuli.	Chemotaxis assay	20203610	2010	Pubchem Assay
PRRID_0680	Mitochondrial DNA Click for more detail	rhabdomyosarcoma cells (others)	NA	NA	Nucleic Acid	Natural	It activates the PMN in circukation and promote the Ca2+ flux and phosphorylation of MAP kinases	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human	Neutrophils	NA	Q9NR96.fasta	Q9NR96	1032	It incites non-specific organ attack and suppresses chemotactic responsess to infective stimuli.	Chemotaxis assay	20203610	2010	Pubchem Assay
PRRID_0691	MsST Click for more detail	Streptococcus thermophilus lacZ (Bacteria)	MNMTEKIQTYLNDPKIVSVNTVDAHSDHKYFESLEEFSEGEMKLRQSLNGKWKIHYAQNTNQVLKDFYKTEFDETDLNFINVPGHLELQGFGSPQYVNTQYPWDGKEFLRPPQVPQESNAVASYVKHFTLNDALKDKKVFISFQGVATSIFVWVNGNFVGYSEDSFTPSEFEISDYLVEGDNKLAVAVYRYSTASWLEDQDFWRLYGIFRDVYLYAIPKVHVQDLFVKGDYDYQTKAGQLDIDLKTVGDYEDKKIKYVLSDYEGIVTEGDASVNGDGELSVSLENLKIKPWSAESPKLYDLILHVLDDDQVVEVVPVKVGFRRFEIKDKLMLLNGKRIVFKGVNRHEFNARTGRCITEEDMLWDIKVMKQHNINAVRTSHYPNQTRWYELCDEYGLYVIDEANLETHGTWQKLGLCEPSWNIPASEPEWLPACLDRANNMFQRDKNHASVIIWSCGNESYAGKDIADMADYFRSVDNTRPVHYEGVAWCREFDYITDIESRMYAKPADIEEYLTTGKLVDLSSVSDKHFASGNLTNKPQKPYISCEYMHTMGNSGGGLQLYTDLEKYPEYQGGFIWDFIDQAIYKTLPNGSEFLSYGGDWHDRPSDYEFCGNGIVFADRTLTPKLQTVKHLYSNIKIAVDEKSVTIKNDNLFEDLSAYTFLARVYEDGRKVSESEYHFDVKPGEEATFPVNFVVEASNSEQIYEVACVLREATEWAPKGHEIVRGQYVVEKISTETPVKAPLNVVEGDFNIGIQGQNFSILLSRAQNTLVSAKYNGVEFIEKGPKLSFTRAYTDNDRGAGYPFEMAGWKVAGNYSKVTDTQIQIEDDSVKVTYVHELPGLSDVEVKVTYQVDYKGRIFVTANYDGKAGLPNFPEFGLEFAIGSQFTNLSYYGYGAEESYRDKLPGAYLGRYETSVEKTFAPYLMPQESGNHYGTREFTVSDDNHNGLKFTALNKAFEFSALRNSTEQIENARHQYELQESDATWIKVLAAQMGVGGDDTW	1026	Nucleic Acid	Natural	It increases the number of CD80+CD11c+and CD86+CD11c+ dendritic cells and CD4+CD25+ regulatory T cells and also induces the production of IL-6.	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Mice	Spleenocytes	LRR	Q99MB1.fasta	Q99MB1	905	It is a potent stimulators of innate immunity.	ELISA	20163626	2010	Pubchem Assay
PRRID_0691	MsST Click for more detail	Streptococcus thermophilus lacZ (Bacteria)	MNMTEKIQTYLNDPKIVSVNTVDAHSDHKYFESLEEFSEGEMKLRQSLNGKWKIHYAQNTNQVLKDFYKTEFDETDLNFINVPGHLELQGFGSPQYVNTQYPWDGKEFLRPPQVPQESNAVASYVKHFTLNDALKDKKVFISFQGVATSIFVWVNGNFVGYSEDSFTPSEFEISDYLVEGDNKLAVAVYRYSTASWLEDQDFWRLYGIFRDVYLYAIPKVHVQDLFVKGDYDYQTKAGQLDIDLKTVGDYEDKKIKYVLSDYEGIVTEGDASVNGDGELSVSLENLKIKPWSAESPKLYDLILHVLDDDQVVEVVPVKVGFRRFEIKDKLMLLNGKRIVFKGVNRHEFNARTGRCITEEDMLWDIKVMKQHNINAVRTSHYPNQTRWYELCDEYGLYVIDEANLETHGTWQKLGLCEPSWNIPASEPEWLPACLDRANNMFQRDKNHASVIIWSCGNESYAGKDIADMADYFRSVDNTRPVHYEGVAWCREFDYITDIESRMYAKPADIEEYLTTGKLVDLSSVSDKHFASGNLTNKPQKPYISCEYMHTMGNSGGGLQLYTDLEKYPEYQGGFIWDFIDQAIYKTLPNGSEFLSYGGDWHDRPSDYEFCGNGIVFADRTLTPKLQTVKHLYSNIKIAVDEKSVTIKNDNLFEDLSAYTFLARVYEDGRKVSESEYHFDVKPGEEATFPVNFVVEASNSEQIYEVACVLREATEWAPKGHEIVRGQYVVEKISTETPVKAPLNVVEGDFNIGIQGQNFSILLSRAQNTLVSAKYNGVEFIEKGPKLSFTRAYTDNDRGAGYPFEMAGWKVAGNYSKVTDTQIQIEDDSVKVTYVHELPGLSDVEVKVTYQVDYKGRIFVTANYDGKAGLPNFPEFGLEFAIGSQFTNLSYYGYGAEESYRDKLPGAYLGRYETSVEKTFAPYLMPQESGNHYGTREFTVSDDNHNGLKFTALNKAFEFSALRNSTEQIENARHQYELQESDATWIKVLAAQMGVGGDDTW	1026	Nucleic Acid	Natural	It increases the number of CD80+CD11c+and CD86+CD11c+ dendritic cells and CD4+CD25+ regulatory T cells and also induces the production of IL-6.	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Mice	Spleenocytes	LRR	Q99MB1.fasta	Q99MB1	905	It is a potent stimulators of innate immunity.	ELISA	20163626	2010	Pubchem Assay
PRRID_0695	murine cytomegalovirus Click for more detail	MCMV (virus)	NA	NA	Nucleic Acid	Natural	Upon recogniton by the TLR, it induces induces the recruitment of adaptor proteins TRIF	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	Endosomes	Leucine-rich Repeat (LRR) Domain	O15455.fasta	O15455	904	it lead to the secretion of IFN-Œ≤	NA	20620129	2010	Pubchem Assay
PRRID_0695	murine cytomegalovirus Click for more detail	MCMV (virus)	NA	NA	Nucleic Acid	Natural	Upon recogniton by the TLR, it induces induces the recruitment of adaptor proteins TRIF	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	Endosomes	Leucine-rich Repeat (LRR) Domain	O15455.fasta	O15455	904	it lead to the secretion of IFN-Œ≤	NA	20620129	2010	Pubchem Assay
PRRID_0706	naked dsRNS (poly(I:C)) Click for more detail	Bacteria	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	induced a reduction in maximal mitochondrial respiration	Toll-like receptor 3,7,9 (TLR3/7/9)	Toll-like receptor (TLR)	Human	Human hepatocytes (HepG2 cells)	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	This resultsinto mitochondrial dysfunction which is accompanied by caspase-8	NA	20691286	2010	NA
PRRID_0706	naked dsRNS (poly(I:C)) Click for more detail	Bacteria	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	induced a reduction in maximal mitochondrial respiration	Toll-like receptor 3,7,9 (TLR3/7/9)	Toll-like receptor (TLR)	Human	Human hepatocytes (HepG2 cells)	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	This resultsinto mitochondrial dysfunction which is accompanied by caspase-8	NA	20691286	2010	NA
PRRID_0717	ODN with CpG motif Click for more detail	Bacteria	NA	NA	Nucleic Acid	Synthetic	ODN and CpG motifs activates the TLR9, which results in the activation of the downstream signalling cascade.	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Raw 264.7 macrophage cell line	Cells of the immune system and initially localized at ER	Leucine-rich Repeat (LRR) Domain	Q9EQU3.fasta	Q9EQU3	1032	Pleiotropic immune responses and regulates apoptosis	NA	20739833	2010	Pubchem Assay
PRRID_0717	ODN with CpG motif Click for more detail	Bacteria	NA	NA	Nucleic Acid	Synthetic	ODN and CpG motifs activates the TLR9, which results in the activation of the downstream signalling cascade.	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Raw 264.7 macrophage cell line	Cells of the immune system and initially localized at ER	Leucine-rich Repeat (LRR) Domain	Q9EQU3.fasta	Q9EQU3	1032	Pleiotropic immune responses and regulates apoptosis	NA	20739833	2010	Pubchem Assay
PRRID_0751	poly U Click for more detail	NA	NA	NA	Nucleic Acid	Synthetic	It led to the activation of NF-Œ∫B and upregulate the expression of the antiapoptotic protein Bcl-2.	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	Lung cancer cells	NA	Q9NYK1.fasta	Q9NYK1	1049	This resulted into increased tumor cell survival and resistance to apoptosis induced by chemotherapy.	ELISA	20237413	2010	Pubchem Assay
PRRID_0751	poly U Click for more detail	NA	NA	NA	Nucleic Acid	Synthetic	It led to the activation of NF-Œ∫B and upregulate the expression of the antiapoptotic protein Bcl-2.	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	Lung cancer cells	NA	Q9NYK1.fasta	Q9NYK1	1049	This resulted into increased tumor cell survival and resistance to apoptosis induced by chemotherapy.	ELISA	20237413	2010	Pubchem Assay
PRRID_0752	poly-UG dsRNA Click for more detail	Bacteria	NA	NA	Nucleic Acid	Synthetic	production of IFN-‚ç∫, IL-6 and IL-1Œ≤	Toll-like receptor 3 (TLR3)/Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Chicken	Spleenocytes	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	Immunostimulation and inflammation	NA	20692289	2010	NA
PRRID_0752	poly-UG dsRNA Click for more detail	Bacteria	NA	NA	Nucleic Acid	Synthetic	production of IFN-‚ç∫, IL-6 and IL-1Œ≤	Toll-like receptor 3 (TLR3)/Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Chicken	Spleenocytes	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	Immunostimulation and inflammation	NA	20692289	2010	NA
PRRID_0753	polyadenylic-polyuridylic acid Click for more detail	Bacteria	NA	NA	Nucleic Acid	Synthetic	Their binding leads to the enhanced production of IFN-	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	mDCs	Leucine-rich Repeat (LRR) Domain	O15455.fasta	O15455	904	It resulted in direct activation NK cells leading to high IFN-Œ≥ production.	NA	20639488	2010	Pubchem Assay
PRRID_0753	polyadenylic-polyuridylic acid Click for more detail	Bacteria	NA	NA	Nucleic Acid	Synthetic	Their binding leads to the enhanced production of IFN-	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	mDCs	Leucine-rich Repeat (LRR) Domain	O15455.fasta	O15455	904	It resulted in direct activation NK cells leading to high IFN-Œ≥ production.	NA	20639488	2010	Pubchem Assay
PRRID_0754	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	Secretion of proinflammatory cytokines such as TFG-Œ≤ and IL-6	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	DF-MSCs & DP-MSCs	Tooth	Leucine-rich Repeat (LRR) Domain	O15455.fasta	O15455	904	It has the role in the inflammation.	NA	20731536	2010	Pubchem Assay
PRRID_0754	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	Secretion of proinflammatory cytokines such as TFG-Œ≤ and IL-6	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	DF-MSCs & DP-MSCs	Tooth	Leucine-rich Repeat (LRR) Domain	O15455.fasta	O15455	904	It has the role in the inflammation.	NA	20731536	2010	Pubchem Assay
PRRID_0755	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	It results mTOR positively regulates interleukin 1 beta (IL-1Œ≤), tumor necrosis factor alpha (TNFŒ±) and interferon beta (IFN-Œ≤) expression, but negatively regulates IL-12p70 expression in keratinocytes	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	Keratinocytes	Leucine-rich Repeat (LRR) Domain	O15455.fasta	O15455	904	It leads to the inflammatory response from the immune system leads to the clearance of pathogens	NA	20728939	2010	Pubchem Assay
PRRID_0755	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	It results mTOR positively regulates interleukin 1 beta (IL-1Œ≤), tumor necrosis factor alpha (TNFŒ±) and interferon beta (IFN-Œ≤) expression, but negatively regulates IL-12p70 expression in keratinocytes	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	Keratinocytes	Leucine-rich Repeat (LRR) Domain	O15455.fasta	O15455	904	It leads to the inflammatory response from the immune system leads to the clearance of pathogens	NA	20728939	2010	Pubchem Assay
PRRID_0756	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	Reduced HIV-1 expression	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	Macrophages	Leucine-rich Repeat (LRR) Domain	O15455.fasta	O15455	904	It leads to the clearance of the pathogen from the system	NA	20719993	2010	Pubchem Assay
PRRID_0756	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	Reduced HIV-1 expression	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	Macrophages	Leucine-rich Repeat (LRR) Domain	O15455.fasta	O15455	904	It leads to the clearance of the pathogen from the system	NA	20719993	2010	Pubchem Assay
PRRID_0757	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	enhance the efficacy of peptide-based cancer vaccines by promoting tumor specific T cell responses	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Mice (Murine)	dendritic cells and macrophages	Leucine-rich Repeat (LRR) Domain	Q99MB1.fasta	Q99MB1	905	It has the role in the inflammation.	NA	20713100	2010	Pubchem Assay
PRRID_0757	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	enhance the efficacy of peptide-based cancer vaccines by promoting tumor specific T cell responses	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Mice (Murine)	dendritic cells and macrophages	Leucine-rich Repeat (LRR) Domain	Q99MB1.fasta	Q99MB1	905	It has the role in the inflammation.	NA	20713100	2010	Pubchem Assay
PRRID_0758	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	NA	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	organotypic Human brain slice cultures	Astrocytes	Leucine-rich Repeat (LRR) Domain	O15455.fasta	O15455	904	It improves the survival of neurons	NA	20706642	2010	Pubchem Assay
PRRID_0758	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	NA	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	organotypic Human brain slice cultures	Astrocytes	Leucine-rich Repeat (LRR) Domain	O15455.fasta	O15455	904	It improves the survival of neurons	NA	20706642	2010	Pubchem Assay
PRRID_0759	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	NA	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	CNS	NA	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	It causes neurodegeneration	NA	20706642	2010	NA
PRRID_0759	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	NA	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	CNS	NA	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	It causes neurodegeneration	NA	20706642	2010	NA
PRRID_0760	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	induced the secretion of IL-6 and IL-8	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	primary corneal epithelial cells and primary conjunctival epithelial cells, endothelial cells and fibroblasts	Leucine-rich Repeat (LRR) Domain	O15455.fasta	O15455	904	It has the role in the inflammation.	NA	20703156	2010	Pubchem Assay
PRRID_0760	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	induced the secretion of IL-6 and IL-8	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	primary corneal epithelial cells and primary conjunctival epithelial cells, endothelial cells and fibroblasts	Leucine-rich Repeat (LRR) Domain	O15455.fasta	O15455	904	It has the role in the inflammation.	NA	20703156	2010	Pubchem Assay
PRRID_0761	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	It results into the induction of type I IFNs	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Chicken	Spleenocytes	Leucine-rich Repeat (LRR) Domain	D6R3C9.fasta	D6R3C9	66	Immunostimulation	NA	20692289	2010	Pubchem Assay
PRRID_0761	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	It results into the induction of type I IFNs	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Chicken	Spleenocytes	Leucine-rich Repeat (LRR) Domain	D6R3C9.fasta	D6R3C9	66	Immunostimulation	NA	20692289	2010	Pubchem Assay
PRRID_0762	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	Their binding leads to the enhanced production of type I IFNs	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	mDCs	Leucine-rich Repeat (LRR) Domain	O15455.fasta	O15455	904	It resulted in direct activation NK cells leading to high IFN-Œ≥ production in synergy with mDC-released soluble mediators induced by dsRNA	NA	20639488	2010	Pubchem Assay
PRRID_0762	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	Their binding leads to the enhanced production of type I IFNs	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	mDCs	Leucine-rich Repeat (LRR) Domain	O15455.fasta	O15455	904	It resulted in direct activation NK cells leading to high IFN-Œ≥ production in synergy with mDC-released soluble mediators induced by dsRNA	NA	20639488	2010	Pubchem Assay
PRRID_0763	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	Their binding leads to the enhanced production of type I IFNs	RIG-1	Rig-like receptor (RLR)	Human	Nk cell and mDCs	NA	O95786.fasta	O95786	925	It resulted in direct activation NK cells leading to high IFN-Œ≥ production in synergy with mDC-released soluble mediators induced by dsRNA	NA	20639488	2010	Pubchem Assay
PRRID_0763	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	Their binding leads to the enhanced production of type I IFNs	RIG-1	Rig-like receptor (RLR)	Human	Nk cell and mDCs	NA	O95786.fasta	O95786	925	It resulted in direct activation NK cells leading to high IFN-Œ≥ production in synergy with mDC-released soluble mediators induced by dsRNA	NA	20639488	2010	Pubchem Assay
PRRID_0764	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	Their binding leads to the enhanced production of type I IFNs	RIG-1	Rig-like receptor (RLR)	Human	Nk cell and mDCs	NA	O95786.fasta	O95786	925	It resulted in direct activation NK cells leading to high IFN-Œ≥ production in synergy with mDC-released soluble mediators induced by dsRNA	NA	20639488	2010	Pubchem Assay
PRRID_0764	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	Their binding leads to the enhanced production of type I IFNs	RIG-1	Rig-like receptor (RLR)	Human	Nk cell and mDCs	NA	O95786.fasta	O95786	925	It resulted in direct activation NK cells leading to high IFN-Œ≥ production in synergy with mDC-released soluble mediators induced by dsRNA	NA	20639488	2010	Pubchem Assay
PRRID_0765	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	The binding of ligand to TLR3 results into induction of type I interferon inducible antiviral factors, including APOBEC3G and tetherin.	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	Monocyte-derived macrophages	Leucine-rich Repeat (LRR) Domain	O15455.fasta	O15455	904	Activation of TLR-3 inhibits human immunodeficiency virus (HIV) replication and hence inhibits HIV-1 infection of macrophages	ELISA	20636339	2010	Pubchem Assay
PRRID_0765	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	The binding of ligand to TLR3 results into induction of type I interferon inducible antiviral factors, including APOBEC3G and tetherin.	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	Monocyte-derived macrophages	Leucine-rich Repeat (LRR) Domain	O15455.fasta	O15455	904	Activation of TLR-3 inhibits human immunodeficiency virus (HIV) replication and hence inhibits HIV-1 infection of macrophages	ELISA	20636339	2010	Pubchem Assay
PRRID_0766	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	The binding results into secretion of low amounts of IL-12(p70) and high levels of IL-10 ompared with adult cells	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	Cord blood cells	Leucine-rich Repeat (LRR) Domain	O15455.fasta	O15455	904	NA	NA	20636030	2010	Pubchem Assay
PRRID_0766	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	The binding results into secretion of low amounts of IL-12(p70) and high levels of IL-10 ompared with adult cells	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	Cord blood cells	Leucine-rich Repeat (LRR) Domain	O15455.fasta	O15455	904	NA	NA	20636030	2010	Pubchem Assay
PRRID_0767	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	It's binding activate type I IFN response	MDA5	Rig-like receptor (RLR)	NA	NA	NA	NA	NA	NA	It results into the anti-viral response by the immune system of host	NA	20620129	2010	NA
PRRID_0767	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	It's binding activate type I IFN response	MDA5	Rig-like receptor (RLR)	NA	NA	NA	NA	NA	NA	It results into the anti-viral response by the immune system of host	NA	20620129	2010	NA
PRRID_0768	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	It stimulates the release of TNF-‚ç∫, IL-6 and CXCL1, and nitric oxide by microglia	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice (Murine)	Primary Microglial cells	Leucine-rich Repeat (LRR) Domain	Q9QUK6.fasta	Q9QUK6	835	Poly(I:C) increases microglial phagocytosis and intracellular killing of Escherichia coli K1, a pathogenic encapsulated bacterial strain	Phagocytosis assay	20599470	2010	Pubchem Assay
PRRID_0768	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	It stimulates the release of TNF-‚ç∫, IL-6 and CXCL1, and nitric oxide by microglia	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice (Murine)	Primary Microglial cells	Leucine-rich Repeat (LRR) Domain	Q9QUK6.fasta	Q9QUK6	835	Poly(I:C) increases microglial phagocytosis and intracellular killing of Escherichia coli K1, a pathogenic encapsulated bacterial strain	Phagocytosis assay	20599470	2010	Pubchem Assay
PRRID_0769	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	It's binding induces the production of IL6, IL8, MMP3 and MMP3	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	Fibroblast Like Synoviocytes (FLS)	Leucine-rich Repeat (LRR) Domain	O15455.fasta	O15455	904	It has a role in the pathogenesis of juvenile idiopathic arthritis and cartilage destruction	ELISA	20571165	2010	Pubchem Assay
PRRID_0769	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	It's binding induces the production of IL6, IL8, MMP3 and MMP3	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	Fibroblast Like Synoviocytes (FLS)	Leucine-rich Repeat (LRR) Domain	O15455.fasta	O15455	904	It has a role in the pathogenesis of juvenile idiopathic arthritis and cartilage destruction	ELISA	20571165	2010	Pubchem Assay
PRRID_0770	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	Poly[I:C] stimulate the activaion of natural killer cells which leads to the secretion of IL-6 ,TNF-‚ç∫ and IFN-	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	Natural Killer cells from peripheral blood	Leucine-rich Repeat (LRR) Domain	O15455.fasta	O15455	904	It has a immunostimulatory role	Flex-Set cytokine assay	20427039	2010	Pubchem Assay
PRRID_0770	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	Poly[I:C] stimulate the activaion of natural killer cells which leads to the secretion of IL-6 ,TNF-‚ç∫ and IFN-	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	Natural Killer cells from peripheral blood	Leucine-rich Repeat (LRR) Domain	O15455.fasta	O15455	904	It has a immunostimulatory role	Flex-Set cytokine assay	20427039	2010	Pubchem Assay
PRRID_0771	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	Poly[I:C] stimulate the activaion of natural killer cells which leads to the secretion of IL-6 ,TNF-‚ç∫ and IFN-	MDA5	Rig-like receptor (RLR)	Human	Natural Killer cells from peripheral blood	NA	Q53TB6.fasta	Q53TB6	435	It has a immunostimulatory role	Flex-Set cytokine assay	20427039	2010	Pubchem Assay
PRRID_0771	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	Poly[I:C] stimulate the activaion of natural killer cells which leads to the secretion of IL-6 ,TNF-‚ç∫ and IFN-	MDA5	Rig-like receptor (RLR)	Human	Natural Killer cells from peripheral blood	NA	Q53TB6.fasta	Q53TB6	435	It has a immunostimulatory role	Flex-Set cytokine assay	20427039	2010	Pubchem Assay
PRRID_0772	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	Cells infected with viruses triggering MDA5-dependent IFN induction	RIG-1	Rig-like receptor (RLR)	NA	NA	NA	NA	NA	NA	IFN triggers the expression of antiviral proteins, promote the destruction of infected cells by natural killer cells, and facilitate the production of neutralizing antibodies and cytotoxic T-cell responses.	NA	20354786	2010	NA
PRRID_0772	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	Cells infected with viruses triggering MDA5-dependent IFN induction	RIG-1	Rig-like receptor (RLR)	NA	NA	NA	NA	NA	NA	IFN triggers the expression of antiviral proteins, promote the destruction of infected cells by natural killer cells, and facilitate the production of neutralizing antibodies and cytotoxic T-cell responses.	NA	20354786	2010	NA
PRRID_0773	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	It induces the release of microparticles by the macrophages	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice (Murine)	Macropahes	LRR	Q9QUK6.fasta	Q9QUK6	835	It leads to the release of MPs which act as the novel signals for innate immunity	Griess assay	20335312	2010	Pubchem Assay
PRRID_0773	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	It induces the release of microparticles by the macrophages	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice (Murine)	Macropahes	LRR	Q9QUK6.fasta	Q9QUK6	835	It leads to the release of MPs which act as the novel signals for innate immunity	Griess assay	20335312	2010	Pubchem Assay
PRRID_0782	Resiquimod (R-848) Click for more detail	imidazoquinoline (others)	CCOCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2N	NA	Nucleic Acid	Synthetic	The binding results into the robust TNF-‚ç∫ and IL-12 production	Toll-like receptor 7/8 (TLR7/8)	Toll-like receptor (TLR)	Human	APCs	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	NA	NA	20636030	2010	NA
PRRID_0782	Resiquimod (R-848) Click for more detail	imidazoquinoline (others)	CCOCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2N	NA	Nucleic Acid	Synthetic	The binding results into the robust TNF-‚ç∫ and IL-12 production	Toll-like receptor 7/8 (TLR7/8)	Toll-like receptor (TLR)	Human	APCs	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	NA	NA	20636030	2010	NA
PRRID_0785	RNA40 Click for more detail	HIV-1 (virus)	NA	NA	Nucleic Acid	Natural	Activate IRF-7 mediated by MyD88	Toll-like receptor 1/2 (TLR1/2)	Toll-like receptor (TLR)	Human	NA	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	Activate pDCs	NA	20672047	2010	NA
PRRID_0785	RNA40 Click for more detail	HIV-1 (virus)	NA	NA	Nucleic Acid	Natural	Activate IRF-7 mediated by MyD88	Toll-like receptor 1/2 (TLR1/2)	Toll-like receptor (TLR)	Human	NA	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	Activate pDCs	NA	20672047	2010	NA
PRRID_0790	single-stranded RNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	Activates NF-KB and MAPK which lead to the production of cytokines as TNF and other proinflammatory proteins	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	NA	Leucine-rich Repeat (LRR) Domain	Q9NYK1.fasta	Q9NYK1	1049	It coauses the inflammation	NA	20740341	2010	Pubchem Assay
PRRID_0790	single-stranded RNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	Activates NF-KB and MAPK which lead to the production of cytokines as TNF and other proinflammatory proteins	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	NA	Leucine-rich Repeat (LRR) Domain	Q9NYK1.fasta	Q9NYK1	1049	It coauses the inflammation	NA	20740341	2010	Pubchem Assay

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